P246 Disease control and unmet needs among moderate to severe ulcerative colitis patients treated with conventional therapies in Europe: The UC CARES (Ulcerative Colitis condition, attitude, resources and educational study) study

Abstract

history) and disease (age of disease onset, disease location, disease phenotype and surgical CD history) related variables were extracted. CR was defined as an initiation or change in medical treatment for recurrent symptoms with endoscopic or radiological evidence of active disease. Time to CR was measured in months after surgery. Univariate analysis was performed using the log rank test and multivariate analysis was performed using cox regression analysis. Results: One hundred and thirty-one subjects had long term follow up data. Fifty-two developed CR (39.7%). On univariate analysis, ileocolic (p = 0.053) and recurrent surgery (p = 0.057) were associated with earlier CR. Multivariate analysis demonstrates that ileocolonic disease (p = 0.013) and recurrent surgery (p = 0.024) are both significantly associated with the presence of earlier CR when adjusting for all disease related variables.