P24.11: Fetal neurosonographic aspects of the Zika virus infection

Abstract

Zika virus epidemic occurred in Brazil in 2015 was associated with an increase in the number of cases of microcephaly. Currently, the association between fetal central nervous system (CNS) onset and congenital infection by zika virus is known. The aim of this study was to describe the main neurosonographic manifestations observed in cases of zika virus infection with fetal brain lesions followed up during 2016 in the fetal neurology sector of the Federal University of São Paulo and in the centro paulista de medicina fetal. 10 pregnant women with suspected changes in fetal brain morphology and diagnosed with zika virus infection were followed up during 2016. Maternal diagnosis was confirmed by serology or urine test. In all cases, a detailed examination of the fetal CNS morphology was performed by neurosonography to describe the main cerebral changes observed. Main neurosonographic findings were: mild ventricumegaly 4 cases (40%); periventricular calcifications 6 cases (60%); calcifications in caudate nucleus 7 (70%); thalamic calcifications 3 cases (30%); polymicrogyria 2 cases (20%); schizencephaly 2 cases (20%); severe ventriculomegaly 6 (60%); cerebellar hypotrophy 5 cases (60%); corpus callosum dysgenesis 10 cases (100%); cerebral sulcation delay 10 (100%); increased subarachnoid space 4 (40%); microcephaly 4 (40%). Zika virus infection can lead to changes in the fetal CNS, although these manifestations are not specific for this infection. However, detailed assessment of brain morphology is very important to correct counselling and follow-up of these cases.