P23, a novel mammalian nucleic acid-binding protein with homology to the yeast ribosomal protein YL43

Abstract

When separating perchloric acid-soluble proteins from cell cultures and tissues by chromatography on single stranded DNA agarose columns, a novel mammalian protein with extreme affinity for DNA was isolated. Cellular localization, amino acid composition and the N-terminal sequence suggest that the protein is a ribosomal protein with extensive sequence homology to the ribosomal protein, YL43, from Saccharomyces cerevisiae.