P23.03 Novel Serum Extracellular Vesicles Based miR-153-3p Biomarker Combined to a Prediction Model for Determining Early-Stage Lung Cancer

Abstract

Lung cancer (LC) is a highly heterogeneous tumor with being the lead cause of cancer incidence and mortality. Hence, the targeting of the early-stage lung cancer (ESLC) at initial stages within <20mm size of lung nodules (LNs) is crucial for the detection and therapeutics advancement of LC. The study aims to discover novel circulating serum extracellular vesicles (sEVs) miRNA biomarkers associated with radiomics-clinical features for developing a prediction model, and tackling early-stage lung cancer and differentiating from benign lung nodules (BNs).