Abstract
Thyroid transcription factor 1 (TTF-1) is a protein which regulates transcription of genes specific for thyroid, lung, and diencephalon, and is used in anatomic pathology as a marker to determine if a tumor arises from lung or thyroid. TTF-1 positive rate in endometrial carcinoma (Grade 1-2) is as rare as 2%. We present a solitary pulmonary metastasis case from TTF-1 positive endometrioid carcinoma. A 84-year-old woman was addressed to our institution for an abnormal shadow in the chest. Chest CT showed 14mm nodule in the right lower lobe. She had a previous history of surgically resected endometrioid carcinoma (Grade 2) of the uterine corpus. Video assisted thoracic surgery was performed for diagnostic and therapeutic purposes. Intra-operative diagnosis was suspected lung metastasis of endometrioid carcinoma. Immunohistochemical staining revealed positive estrogen receptor, TTF-1 and PAX8. Based on the results, we made a diagnosis of metastatic endometrioid carcinoma. The postoperative course was uneventful. TTF-1 positive endometrioid carcinoma is rare. Medical history and immunohistochemistry are useful for differentiating from primary lung cancer. TTF-1 positive endometrioid carcinomas have reported a poor prognosis and require careful follow-up.
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