Abstract
Early life stress (ELS), including childhood trauma, is often associated with an increased risk of developing Borderline Personality Disorder (BPD) later in life. Several studies have indeed suggested that individual genetic variations may increase the risk for this disorder following an exposure to ELS, a phenomenon called Gene x Environment (G×E) interaction. Interestingly, we have found that FoxO1 gene shows GxE interactions and predicts adult depression in subjects exposed to ELS. Here, we wanted to assess whether epigenetic alterations, in terms of microRNAs (miRNAs), occurring on FoxO1 could explain the association between ELS and BPD at adulthood.
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