Abstract
pathogens, cephalosporins and penicillins were used only in 44 and 10 cases, respectively. Empiric anaerobic coverage was given in 130 episodes (38%), although only five co-pathogens were anaerobes. Multivariate Cox regression analysis showed that neither susceptible antibiotic coverage (compared to non-susceptible; hazard ratio, 0.7, 95% CI, 0.4-1.2) nor exaggerated broad-spectrum use (hazard ratio, 1.1, 0.8-1.5) changed remission rates.
Highlights
Empiric broad-spectrum antibiotic treatment for orthopaedic implant infections after surgical lavage is common practice while awaiting microbiological results, but lacks evidence
Our objective was to question the indication of broadspectrum empiric therapy in this clinical setting
Multivariate Cox regression analysis showed that neither susceptible antibiotic coverage nor exaggerated broad-spectrum use changed remission rates
Summary
Our objective was to question the indication of broadspectrum empiric therapy in this clinical setting. Pathogens, cephalosporins and penicillins were used only in 44 and 10 cases, respectively. Empiric anaerobic coverage was given in 130 episodes (38%), only five co-pathogens were anaerobes. Multivariate Cox regression analysis showed that neither susceptible antibiotic coverage (compared to non-susceptible; hazard ratio, 0.7, 95% CI, 0.4-1.2) nor exaggerated broad-spectrum use (hazard ratio, 1.1, 0.8-1.5) changed remission rates
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