P2.13-08 Which Is the Reliable Prognosticator for Early Metastasis and Recurrence of Non- Small Cell Lung Cancer, Related with STAS?

Abstract

In recent years, many studies had investigated the correlation between STAS and the clinical parameters and prognosis of lung cancer. The majority of these studies focused on AdC, and a number of tumor-related factors were considered to be influenced by STAS. The incidence of STAS in AdC ranged from 14.8% to 56.4%, and STAS was demonstrated to have an association with AdC histologic type. For proper movement of lung cancer, correct perioperative evaluation and assessment is crucial, Recently the concept and significance of STAS has great interest. Materials and methods We retrospectively reviewed 171 non-small cell lung cancers, analyzed 45 cases, underwent lobectomy or pneumonectomy with pathology report and medical record. Tumor STAS was defined as detached tumor cells within the air spaces in the lung parenchyma beyond the edge of the main tumor clinicopathological factors, including clinical outcome. Comparison was done with visceral pleural invasion and lymphovascular invasion. STAS was identified in 12 of 45 patients (26.6%). The patients with STAS had a significantly worse 5-year recurrence-free survival (RFS) in stage I, but not in stage II and III. A multivariate analysis showed that the presence of STAS was an independent predictive factor of and an independent prognostic factor (hazard ratio = 3.01; 95% confidence interval, 1.54-5.89; p = 0.0013) in stage I. Positive for STAS, and lymphovascular invasion was 10/45 and positive for STAS, and viscera pleural invasion was 6/45 and all positive lung cancers were 3/45 We found that STAS was detected in 26.6% of surgical resected non-small cell caricnomas, and it was associated with recurrence and worse prognosis in early stage lung cancers. Therefore, we suggest that STAS is a reliable prognosticator and play promising roles for the lung cancer managements.