P2-08-08: Benefit of Preoperative Breast MRI in Patients with Newly Diagnosed Breast Cancer.

Abstract

Abstract Objective: The aim of our study was to evaluate the effect of routinely performed preoperative Breast MRI (pMRI) on the planned therapeutical management of all patients with newly diagnosed Breast cancer. Subjects and Methods: 180 patients with newly diagnosed Breast Cancer between 9/2009 - 12/2010 were enrolled in this retrospective study performed in a certified European Breast Cancer Unit; mean age 60,6 years; 1,5 T MRI ( TIM-Symphony, Siemens Germany). Results: In 53/180 (29,4%) cases the preoperative MRI changed the planned therapeutical management concerning surgical and chemotherapeutical options. In 42/180(23,3%) patients additional lesions were identified only by pMRI, 33/42(78,6%) have been malignant and 8/42(19%) were benign. The real extent of the tumor was detected in 43/53 (81%) cases — group A; a bilateral carcinoma was detected in 4/53 (7,5%) cases — group B; in 6/53 (11,5%) cases the malignant lesion could only be detected with preoperative MRI — group C; for group A the pMRI led to wider excisions with 15 segmental -or quadrant resections and 28 mastectomies; for group B the pMRI resulted in 4 additional lumpectomies; for group C the pMRI caused 4 lumpectomies, 1 segemental resection and 2 mastecomies .5 of 6 patients got neoadjuvant chemotherapy only due to results of pMRI; in 3 of these 5 patiens breast conserving surgery was possible. Histology: DCIS 23/53 (43,4%), invasive cancer 23/53 (43,4%), multicentric/multifocal malignant lesions 7/53 (13,2%). The sensitivity of the pMRI was not influenced by the histology of the lesion, the age of the patient or menopausal status. The maximum periode between initial presentation of the patient and breast surgery was 21 days. Conclusion: In 29,4% of our patients the pMRI resulted in a significant change of the planned therapeutical regime. Histology of the lesion, patients age or menopausal status did not influence the sensitivity of pMRI. There was no relevant delay in the initiation of treatment. Therefore we recommend performing pMRI in breast cancer staging routinely. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-08-08.