Abstract
In this work the effect of the weak combined magnetic fields (MFs) was studied in vivo in heritable animal model of AD: well characterized mice transgenic for mutant APPswe and mutant presenilin 1 (PS1dE9) that cause early onset familial Alzheimer's disease (AD). Transgenic mice (Tg) and control C3H mice were exposed to the same MF at age of 8 months. Mice were also exposed by MF in two groups at the same time (Tg+MF and C3H+MF). A setup for generating a MFs consisted of two pairs of coaxial Helmhollz coils oriented along the geomagnetic field vector. A direct current was supplied to one of the pairs of coils to generate a constant component of MFs with induction of 42 mcT. An alternating current signal produced by a programmable sinusoidal current generator was fed to other pair of coils to create a variable component of MFs with induction of the amplitude of 80 nT. The current signal was the sum of two frequencies of 4.38 and 4.88 Hz. These frequencies correspond to the cyclotron frequencies of glutamic and aspartic acids. After exposure to the MFs, the mice were trained in a Morris water maze for 18 days (four trials per day). Spatial memory was tested on the following day after completion of training with the hidden platform removed. During the test period (60 s), occupancy time spent in each sector was recorded. The MFs improved the memory in Tg animals. The results of the factor analysis demonstrate that factors of the sector preference became statistically significant for Tg groups after MFs exposure. Thus, the data suggest that MFs can be applied for preventive purposes in a group of risk of AD.
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