P2.01-97 Prognostic Factors in Resected Lung Mucinous Adenocarcinoma: Clinical and Pathological Features

Abstract

Mucinous adenocarcinoma is rare subtype of lung adenocarcinoma. This study aimed to discover which factors influenced prognosis of resected lung mucinous adenocarcinoma. From April 1997 to March 2017, we retrospectively reviewed the clinical and pathological features in resected lung mucinous adenocarcinoma patients. We specially focused on KRAS mutation and NRG1 fusion, which were reported that MA often harbored them. We also examined CT findings (solitary type or pneumonic type) and spread through air space (STAS). The Kaplan-Meier method and log -rank test were used for the survival analyses. 57 patients were enrolled to the study. We detected KRAS mutation in 32 patients (56.1%) and NRG1 fusion in one patient (1.8%). G12D was the most common in terms of amino acid change of KRAS mutation (78%). There were no significant differences in overall survival (OS) and disease-free survival (DFS) between patients with KRAS wild type and those with KRAS mutation (p=0.70 and p=0.85[Office1] , respectively). In point of CT finding, there were 42 solitary type of tumors and 15 pneumonic type of tumors. OS and DFS were significantly worse in pneumonic type patients (p<0.01 and p<0.01[Office2] , respectively). STAS was observed in 32 patients. DFS was significantly shorter in patient with STAS (p=0.03) although OS was not(p=0.07).[Office3] Multivariate analysis revealed that CT finding (pneumonic type) was an independent prognostic factor of DFS. Pneumonic type on CT finding was an independent prognostic factor in patients with completely resected lung mucinous adenocarcinoma. KRAS status was not significantly related to the prognosis in our cohort.