P1716: REGULAR HOSPITAL VISITS IMPROVE THE PROGNOSIS OF MULTIPLE MYELOMA PATIENTS

Abstract

Background: Multiple myeloma（MM）is a common hematological cancer. The overall survival rate of individuals with MM has risen significantly in the previous decade, primarily as a result of the advent and advancements of innovative treatments. As a consequence, given the possibility that cancer will progress to the stage of chronic illness, the post management and regular hospital visit of MM patients are particularly important. Although it seems that long term chronic disease management by regular hospital visit has increased medical expenditure, from the perspective of whole process treatment, it is the best way to achieve standardized treatment and monitoring and may improve the prognosis of MM patients The regular hospital visits means regular hematologist visits with regular treatment and monitor. Irregular hospital visits means visits to other hospital divisions or with no hospital visits. Aims: The aims of this study were to investigate the relationship between regular hospital visits and prognosis of MM and to suggest methods to avoid poor prognoses in MM. Methods: We performed a multicenter retrospective analysis of data from 832 MM patients across 9 centers in China from 2006 to 2020. Sociodemographic (including whether regular hospital visits) and clinical factors at diagnosis and treatment regimens were recorded, and univariate and multivariate analyses were performed. Results: Overall, 30.3% of patients had irregular hospital visits. Patients with irregular hospital visits levels differed from those with regular hospital visits in that they were more likely to be older, and a higher proportion lived in rural areas, were unemployed, and with lower education levels, had lower annual incomes and lacked insurance. Additionally, compared to patients with regular hospital visits, patients with irregular hospital visits had a higher proportion of international staging system (ISS) stage III classification, time to diagnosis is longer and underwent transplantation less often. Patients with regular hospital visits had a median progression-free survival (PFS) of 52.04months, which was better than that of patients with irregular hospital visits (20.3 months, p < 0.001). Similarly, patients with egular hospital visits had a median overall survival (OS) of 107.4months, which was also better than that of patients with irregular hospital visits (37.1 months, p < 0.001). In the multivariable analysis, patients with regular hospital visits had lower relapse rates and higher survival rates than did those with irregular hospital visits in terms of PFS and OS (hazard ratio (HR) = 1.95, p < 0.001; HR =2.80, p < 0.001, respectively). Summary/Conclusion: Irregular hospital visits may independently predict poor survival in MM patients in China.