Abstract
Our research focuses on metabolic transitions in cells, which coincide with important cellular processes such as differentiation, malignant transformation, immune cell activation, and virus infection. We study what regulates metabolic transitions in cells and how the cellular metabolic state influences cellular identity and function. We have recently found that intracellular asparagine levels are limiting for cancer cell proliferation and are essential for maintenance of mTORC1 activity and downstream anabolic processes. Using this knowledge, we have designed strategies to reduce cancer asparagine consumption and biosynthesis to block tumor growth. Here we will present in vivo data showing the importance of tumor asparagine levels for mTORC1 activity, anabolic metabolism, and tumor growth. We will also propose multiple approaches to target cancer asparagine dependence in the clinic.
Published Version
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