Abstract
oxidase activity. At the same time, nuclear expression of NF-kappa;B proteins (p50 and p65) and cellular expression of protein products of the NF-kappa;B-dependent genes (c-myc, bcl-xl, inos, cox-2) were decreased but expression of the NF-kappa;B inhibitor protein (IuBa) and p53 protein was enhanced in the same tumors. PPh ability to strengthen antitumor effect of the synthetic inhibitors of PA synthesis – polyhexamethyleneguanidine (PMG) and a-difluoromethylornithine (DFMO) – was tested. GTE was shown to be able to sum up its antitumoral effect with PMG one and, being combined with DFMO, to prolong lifetime of tumor-bearing animals. Conclusion: GTE and GTEW, can essentially retard experimental tumor growth. Their molecular pathways include inhibition of PA synthesis and interconversion and also inhibition of NF-kappa;B activation and expression of NF-kappa;B-dependent oncogenes. PPh can strengthen antitumoral effect of PMG and have antioxidant and antitoxic properties. Therefore, GTE and GTEW are perspective for cancer prevention in the cancer risk groups and for treatment of cancer patients. Work is support by STCU, grant #4894. Disclosure of Interest: None Declared
Published Version
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