P1206ARTERIAL STIFFNESS AND PERIODONTITIS IN PERITONEAL DIALYSIS PATIENTS: ARE THEY RELATED?

Abstract

Abstract Background and Aims Arterial stiffness is an important risk factor for cardiovascular disease (CVD) in patients with end-stage renal disease (ESRD). However, little is known about risk factors that contribute to arterial rigidity in peritoneal dialysis (PD) patients. The periodontal diseases are highly prevalent among patients with ESRD. The aim of this study was to evaluate the dental status, incidence and severity of periodontitis among Dalmatian PD patients and to investigate possible correlations with arterial stiffness. Method 24 PD patients, 12 (50 %) men and 12 (50 %) women, aged 54.9 (range 21–79) years were included. Arterial stiffening was estimated by using pulse wave velocity (PWV). To measure PWV Agedio B900 device was used. Oral periodontal status included full mouth plaque score, full mouth bleeding score, periodontal probing depth and clinical attachment loss (CAL), all measured at six sites of each tooth. Also periodontitis stage was determined for each patient. Results Out of 24 PD patients 17 (70.1 %) was suffering from periodontitis. Among those with periodontitis 1 patient (5.9 %) was classified as periodontitis stage I (mild), 6 (35.3 %) as stage II (moderate), 10 (58.8%) as stage III and IV (severe). Significantly positive correlation between PWV, average interdental CAL and average total CAL, among all PD patients were found (R= 0.764, P=0.001), (R= 0.738, P=0.001), respectively, Also, in those PD patients statistically negative correlations between PWV and number of teeth were found (R= -0.565, P=0.012). Among those PD patients with periodontitis statistically positive correlation between PWV, periodontitis stage, interdental CAL, average total CAL and dental plaque were found (R= 0.73, P=0.002),(R= 0.731, P=0.00¸5), (R= 0.72, P=0.005), (R= 0.558, P=0.047), respectively. Conclusion The incidence of peritonitis is high in Dalmatian PD patients and more than half of PD patients had severe stage of periodontitis. Despite small sample size, we showed that those PD patients with more severe periodontitis stage had significantly higher arterial stiffness. Routine dental examination should be suggested for all PD patients. A prospective cohort study needs to link the association of severe periodontitis and CVD and confirm desirable survival outcome on successful treatment of periodontal diseases.