Abstract
P12-06. A 'non-self' mimic of the natural epitope of anti-HIV antibody 2G12 shows enhanced antigenicity
Highlights
AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
The broadly neutralizing antibody 2G12 binds a cluster of high mannose oligosaccharides on the glycan shield of HIV
Inspired by the observation that the non-self sugar D-fructose had a higher affinity for 2G12 than Dmannose, we proposed to chemically synthesise D1 arm mimics displaying fructose-like non-self sugars at the terminus to enhance antigenicity and immunogenicity
Summary
A 'non-self' mimic of the natural epitope of anti-HIV antibody 2G12 shows enhanced antigenicity. KJ Doores*1, Z Fulton, CN Scanlan, MR Wormald, RA Dwek, IA Wilson, DR Burton and BG Davis. Address: 1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA, 2Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA, 3Glycobiology Institute, University of Oxford, Oxford, UK and 4Department of Chemistry, University of Oxford, Oxford, UK. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P172 doi:10.1186/1742-4690-6-S3-P172. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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