P12.01: Reference ranges for fetal myocardial velocities and performance indexa using tissue Doppler at 24–41 weeks of gestation

Abstract

Objectives: To construct gestational age-based reference ranges for tissue Doppler parameters in fetuses from 24 to 41 weeks of gestation. Methods: A prospective cross-sectional observational study involving 207 uncomplicated singleton pregnancies between 24 and 41 weeks of gestation. Myocardial peak velocities and myocardial performance index (MPI’) were measured by tissue Doppler in left and right annulus. Left and right atrioventricular flows were also measured by conventional Doppler and E/E′ ratios calculated. Regression analysis was used to determine gestational-age specific reference ranges and to construct normograms for tissue Doppler parameters. Results: All myocardial peak velocities showed a progressive increase with advancing gestation as well as left MPI’ (Table 1). Right MPI’ remained constant. In contrast, left and right E/E′ showed a progressive decline. Conclusions: Normal data of fetal tissue Doppler parameters during second half of pregnancy are provided. The reported reference values may be useful in future research or clinical studies of fetal cardiac function.