P1199 An Inflammatory Bowel Diseases Integrated Resources Portal (IBDIRP)

Abstract

Abstract Background Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease (CD), is a chronic and debilitating gastrointestinal disorder that affects millions of people worldwide. Research on IBD has generated massive amounts of data, including literature, metagenomics, metabolism, bioresources, and databases. We aim to create an IBD Integrated Resources Portal (IBDIRP) that provides the most comprehensive resources for IBD. Methods An integrated platform was developed that provides information on different aspects of IBD research resources, such as single nucleotide polymorphism, genes, transcriptomics, microbiota, metabolism, single cells, and other resources. Valuable and comprehensive IBD-related data were collected from PubMed, Google, GMrepo, gutMega, gutMDisorder, Single-cell Portal, and other sources. Then, the data were systematically sorted, and these resources were manually curated. Results We systematically sorted and cataloged more than 312 unique risk single nucleotide polymorphism associated with IBD in the single nucleotide polymorphism section. We presented over 890 IBD-related genes based on the database collection in the gene section. We also obtained 153 manually curated IBD transcriptomics data, including 12,388 samples, on the GEO database. The sorted IBD-related microbiota data from three primary microbiome databases (GMrepo, gutMega, and gutMDisorder) were available for download. We selected 23,149 IBD-related taxonomic records from these databases. Additionally, we collected 24 IBD metabolism studies with 2,896 participants in the metabolism section. We introduced two interactive single-cell data plug-in units that provided data visualization based on cells and genes. Finally, we listed 18 significant IBD web resources, such as the official ECCO and IOIBD websites, IBD scoring tools, IBD genetic and multi-omics resources, IBD biobanks, and other useful research resources. Conclusion The IBDIRP website is the first integrated resource for global IBD researchers. This portal will help researchers by providing comprehensive knowledge and enabling them to reinforce the multi-dimensional impression of IBD. The IBDIRP website is accessible via www.ibdirp.com.