P1124 Nutritional assessment and validation of GLIM Criteria in Inflammatory Bowel Disease patients

Abstract

Abstract Background There is currently no validated method of assessing nutritional status in non-hospitalised patients with inflammatory bowel disease (IBD). The Global Leadership Initiative on Malnutrition (GLIM) has developed criteria for malnutrition including phenotypic criteria (low BMI, and reduced fat-free mass index (FFM)) and etiologic criteria: reduced food intake or malabsorption and chronic inflammation. In the GLIM algorithm, malnutrition is diagnosed by a combination of at least one phenotypic and at least one etiologic criterion. Gender differences in nutritional indices may be relevant, especially variables assessing weight loss, nutritional intake and digestive symptoms, where different eating habits and symptom expression are known between the sexes. The aim of the study is to validate the GLIM criteria in patients with IBD, including the gender perspective, and to assess the influence of psychosocial factors. Methods Multicentre, prospective, observational, analytical study in non-hospitalised IBD patients. A total of 368 patients with a 1:1 male to female ratio will be included. At the baseline visit GLIM criteria will be assessed along with other nutritional parameters, clinical and demographic characteristics of IBD. Validation of the GLIM criteria will be done with the 6 and 9 month incidence of complications associated with malnutrition (hospitalisations, emergency department visits, medical consultations, IBD complications, surgery and quality of life impairment), with specific analysis by gender and type of IBD. Results To date, a total of 204 IBD patients have been included (104 women; 104 with Crohn's disease [CD], 97 with ulcerative colitis [UC] and 3 with non-specific colitis); with a median age of 52 (SD 14.3) years. The prevalence of malnutrition according to GLIM criteria was 18.1% and 44.1% of patients were at risk of malnutrition, 20.1% by phenotypic criteria and 24% by etiological criteria. In the subgroup analysis, 20.2% of CD patients and 16.5% of UC patients were malnourished according to GLIM criteria. Risk of malnutrition was found in 45.1% and 39.2% in CD and UC, respectively. Conclusion The prevalence of undernutrition according to GLIM criteria is higher in CD than in UC.