P1-103: Clinical value of computed tomography and fluorine-18 fluorodeoxyglucose positron remission tomography in diagnosis of mediastinal mestastasis of non-small cell lung cancer

Abstract

TO compare the clinical value of computed tomography (CT) and fluorine-18 fluorodeoxyglucose positron remission tomography (FDG-PET) in diagnosis of mediastinal metastasis of non-small cell lung cancer (NSCLC). From 2004 to 2006 75 patients with respectable NSCLC underwent CT and FDG-PET with an interval of 2 weeks and then underwent thoracotomy for clearance of mediastinal lymph nodes or biopsy of the mediastinal lymph nodes via mediastinoscopy. The specimens of mediastinal lymph nodes underwent HE staining and PCNA/Ki67 immunohistochemical staining.The sensitivity, specificity, accuracy, positive prediction value, and negative prediction value in diagnosis of metastasis of mediastinal lymph nodes of these 2 procedures were compared. The sensitivity, specificity, accuracy, positive prediction value, and negative prediction value in diagnosis of metastasis of mediastinal lymph nodes were 91.2%, 85.5%, 94.2%, 93.1%, 73.1% respectively for FDG-PET, and were 81.3%, 55.1%, 72.4%, 84.1%, 41.5% respectively for CT. The sensitivity rate was 98% for CT plus FDG-PET. PET is superior to CT in diagnosis of metastasis of MSCLC to mediastinal lymph nodes. PET+CT significantly increases the sensitivity in diagnosi Non-small cell lung cancer; Radioactive tracers; Tomography, emission-computed; Lymph nodes, mediastinal