P08.16: Systematic thickness analysis of the adipose tissue around the fetal arm across gestation using 2D ultrasound images

Abstract

year. Results: Three cases of intrauterine growth restriction (IUGR) at 35 and 29 weeks presented an aorta abdominal intima thickening and a condensation of the elastic fibers forming an evident internal elastic membrane with the presence of inflammatory elements, such as macrophages and activated endothelial cells. Two monochorionic twin pregnancies hesitated with the death of triplets at 25 weeks (IUGR and twin-to-twin transfusion syndrome); they presented an aortic hemorrhagic peri-adventitial dissociation. In both cases were present fetal Doppler abnormalities, in particular an increase of the systolic velocity of umbilical artery in presence of IUGR and an absent diastolic flow and ductus venosus alterations in twins. A Down fetus at 22 weeks showed a sub occlusive thrombosis of the abdominal aorta with delamination of the aortic wall and the presence of media-intimal foamy macrophages, without Doppler alterations in utero. Finally, a fetus with Potter’s syndrome at 23 weeks showed a partially organized thrombosis of the abdominal aorta and renal arteries with delamination of the wall and the presence of media-intimal foamy macrophages, as in IUGR ones. Conclusions: all the fetal intrauterine diseases described might be associated to a specific histological arterial findings which could represent underlying conditions predisposing of hypertension and vascular damage in adult life.