Abstract
Objective. To clarify the developmental activity of the autonomic nervous system (ANS) of the normal fetus and intrauterine growth restriction (IUGR) cases using fetal magnetocardiography (FMCG). Subjects and Methods. Normal pregnancy (n = 35) and IUGR (n = 12) cases at 28–39 and 32–37 weeks of gestation, respectively, were included in this study. The R-R interval variability was used to calculate the coefficient of variance (CVRR) and low frequency/high frequency (LF/HF) ratio. Results. The value of CVRR in the normal pregnancy group displayed a slight increasing trend with gestational age. However, no such trend was observed in the IUGR group. In contrast, the LF/HF ratio in both the normal pregnancy group and the IUGR group clearly increased over the gestational period; the normal group showing statistical significance. Conclusion. The development of fetal ANS activity in IUGR cases might differ from that observed in the normal pregnancy group, and this may facilitate early detection of IUGR.
Highlights
Intrauterine growth restriction (IUGR) delays or terminates intrauterine fetal development; abnormal fetal condition is displayed as the pregnancy progresses
The normal pregnancy group was divided into three groups for classifying one-way ANOVA analysis of CVRR and low frequency/high frequency (LF/HF) as follows: Group (A): 28–31 weeks of pregnancy (8th month of pregnancy); Group (B): 32–35 weeks of pregnancy
To assess fetal autonomic nervous system (ANS) function, Shields and Schifrin evaluated fetal heart rate variability derived from fetal cardiotocography and respiratory movements [20]
Summary
To clarify the developmental activity of the autonomic nervous system (ANS) of the normal fetus and intrauterine growth restriction (IUGR) cases using fetal magnetocardiography (FMCG). The value of CVRR in the normal pregnancy group displayed a slight increasing trend with gestational age. No such trend was observed in the IUGR group. The LF/HF ratio in both the normal pregnancy group and the IUGR group clearly increased over the gestational period; the normal group showing statistical significance. The development of fetal ANS activity in IUGR cases might differ from that observed in the normal pregnancy group, and this may facilitate early detection of IUGR
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