Abstract
Background The majority of Human Immunodeficiency Virus (HIV)infected infants in the developing world progress to AIDS or death within the first year of life. Although a small minority become slow-progressors, the determinants of slow-progression remain to be elucidated. In this context the interactions between the characteristics of the maternal virus transmitted and the infants' adaptive immune responses are likely to be important. We undertook this study to elucidate the contribution of viral and host factors to HIV progression in perinatally-infected infants.
Highlights
The majority of Human Immunodeficiency Virus (HIV)infected infants in the developing world progress to AIDS or death within the first year of life
Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time
We studied a subgroup of 8 infants: 3 Progressors (P) and 5 Slow-Progressors (SP) with C-clade HIV infection, from a well-characterized sub-Saharan infant cohort. 19 longitudinal virus isolates were extracted from plasma samples by CD44-positive selection
Summary
The majority of Human Immunodeficiency Virus (HIV)infected infants in the developing world progress to AIDS or death within the first year of life. Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time JG Prado*1, A Prendergast1, C Thobakgale2, C Juarez1, A Tudor-Williams3, T Ndung'u2, BD Walker4 and P Goulder1 Address: 1University of Oxford, Fundacion irsiCaixa, Badalona, Spain, 2Univeristy of KwaZulu-Natal Durban, Durban, South Africa, 3Department of Paediatrics/Imperial College, London, UK and 4Ragon institute/Massachusetts General Hospital, Boston, MA, USA
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