Abstract
Abstract Background Glioblastoma (GBM) is the most aggressive form of cancer that originates within the central nervous system (CNS). GBM represents 15% of all primary brain tumors, but the cause is unclear, and there is no clear way to prevent it. At the moment, various sophisticated and specific surgical procedures are being used, but there are relatively few simple methods. Material and Methods In this work, we used a turn-on type fluorescent probe that can sense cysteine (Cys) amino acid in the GBM site, and developed topical treatment methods for image-guided surgery (IGS). Results The probe can distinguish the GBM cells and disease sites in clinical samples from individual patients. Besides, the probe has no short or long-term toxicity and immune response. Conclusion The present findings hold promise for the application of the probe to a relatively simple and straightforward following of GBM at clinical sites.
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