Abstract
Aim This study aimed to determine the allelic frequencies of 22 polymorphisms (rs10488631, rs1061170, rs1265159, rs12722489, rs1799964, rs1800629, rs1800630, rs2187668, rs2476601, rs3087243, rs3135388, rs3761847, rs3890745, rs4112788, rs4140564, rs6457617, rs6822844, rs6897932, rs725613, rs7574865, rs800292, rs9888739) in Mexican population. These polymorphisms have been commonly associated with 9 immune diseases such as rheumatoid arthritis, macular degeneration, type 1 diabetes, celiac disease, Graves’ disease, multiple sclerosis, lupus, osteoarthritis and psoriasis. In addition, these polymorphisms are also located in several of the most important immune genes including HLA, STAT4, TNF, TNPO3, IL21, IL2RA, IL7R, MHC, C2, CFH, among others. Method Genotyping was carried out in 100 genomic DNA samples from dried blood spots supplied by the Mexican patients from Gene Test TQMedicine, using custom made multiplex array in Sequenom Massarray System technology. Each patient had a complete physical examination and quantification of blood levels of total immune globulins. The clinical approach was made by TQMCenter’s Immunogenetics department. Results The frequency for all the polymorphism was calculated as well as previous risk alleles for autoimmune diseases determined in Mexican population. Our data shows similarities with those frequencies found in the human genome project and suggest an increase genetic probability for psoriasis and lupus in Mexican population. Patients with several risk alleles show an exacerbated immune response in several clinical conditions, such as dermatitis, rhinitis, food allergies, and sinusitis, among others. The clinical presentation of the diseases was intense and with a poor response to the classic treatment strategies. Conclusion The Mexican population showed a slight frequency of immune associated diseases polymorphism; however those who have several risk alleles shown an exacerbated immune response. Follow up with immune modulators such as glutathione should be performed in this population to control these conditions.
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