P056 ANGIOTENSIN CONVERTING ENZYME I (ACE) ISOFORMS ASSOCIATION, THE GENETIC MARKER IN PARTICULAR, AND PRESENCE OF METABOLIC SYNDROME IN VOLUNTEERS FROM VITÓRIA – ES – BRAZIL

Abstract

Introduction: Socioeconomic and cultural modifications have directly influenced both population's lifestyle habits and health profile, about 75% of world deaths are characterized by the presence of Non-Transmissible Chronic Diseases (NTCD), such as Metabolic Syndrome (MS), which features the concomitance of cardiovascular risk factors, as arterial hypertension, hypercholesterolemia, and diabetes, central fat deposition, and insulin resistance. A two-phase populational study has researched the Angiotensin Converting Enzyme I (ACE) isoforms relating their presence, specially the 90 KDa one, as a possible biological marker in metabolic alterations and hypertension presence. Objectives: This study's objective is to evaluate whether the 90 kDa ACE isoform may be associated to MS presence in a sample population from the city of Vitoria/ES – Brazil (MONICA project, phase II). Methods: 470 volunteers from the second phase of the MONICA project were assessed, including demographic information, clinical and biochemical parameters from biological samples. The Western Blotting technique was used for identifying ACE isoforms in urine, which were classified as follows: Group 1: 65, 90 and 190 kDa isoforms; Group 2: 65 and 90 kDa isoforms; Group 3: 65 and 190 kDa isoforms; and these groups distribution in positive and negative MS groups was also checked. Results: It was observed a higher percentage of women in the sample population (58.7% vs 41.3%), higher percentage of negative MS vs positive (74.8% vs 25.2%); both clinical and biochemical parameters presented significantly higher levels in the positive MS group; and MS was more frequently positive in Group 2 of ACE isoforms (Group 1: 44.4%; Group 2: 50%; Group 3: 5.6%). Conclusion: This study presenting significant results about the parameters that characterize the presence of MS. Further investigation is needed to identify whether there is a possible relation between 90 kDa ACE isoform and MS, increasing the chances of development and worsening the MS, emphasizing this isoform importance as a biological marker for NTCD.