Abstract
Hypofractionated radiation of ‘ultracentral’ lung tumors (abutting the proximal bronchial tree/esophagus), results in high toxicity rates. Normal tissue complication probability (NTCP) and tumor control probability (TCP) models valid in early stage NSCLC have been derived; here, we apply them to evaluate whether higher TCP can be achieved while respecting NTCP constraints and study patient characteristics where TCP couldn’t be improved.
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