Abstract
Background Plasmacytoid dendritic cells (PDCs) have been described to link innate and adaptive immunity. Indeed, these cells are able to capture and present antigens, and produce high amounts of cytokines, especially antiviral type I interferons. PDCs are productively infected by HIV in vitro and in vivo, and several studies have shown a decrease in circulating PDCs number that was correlated with an increase of plasma viral load. However, the inhibitory effect of neutralizing antibodies on PDCs infection has not been yet assessed.
Highlights
Plasmacytoid dendritic cells (PDCs) have been described to link innate and adaptive immunity
We found that PDC GEN2.2 cell line was productively infected by R5 HIV primary isolates
The subset of PDCs expressing FcγRII corresponding to 30–50% of total PDCs population was not recovered
Summary
HIV-1 neutralizing antibodies inhibit plasmacytoid dendritic cells infection. Address: Institute of Virology of Strasbourg, Strasbourg, France * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P57 doi:10.1186/1742-4690-6-S3-P57. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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