Abstract
Background Transcranial direct current stimulation (tDCS) has been tested in heterogeneous refractory epilepsy studies. However, are inconclusive and the parameters were not well defined. Objectives To evaluate safety and efficacy of two protocols of tDCS in adult patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). Methods Randomized clinical trial, placebo-controlled, double-blind with 3 arms; 3 sessions, 5 sessions and placebo stimulation. Frequency of seizures (SZs), interictal epileptiform discharges (IEDs) and adverse effects (AEs) were registered before and after stimulations, and at 30 and 60 days of follow-up. We used descriptive statistics, k-related samples Friedman’s test and relative risk (RR) estimation for analysis. Results We included 28 patients (3d n = 12, 5d n = 8, placebo n8), 16/28 (57%) men, age 37.8(±10.9) years old. We found a significant reduction effect of cathodal tDCS on the frequency of SZs at first (p = 0.001) and second (p = 0.0001) months of follow-up compared to baseline in the 3 arms (p = 0.0001). The mean reduction of SZs frequency at two months in both active groups was significantly higher than placebo (-48% vs −6.25%, p = 0.041) in all groups. Only minor AEs were reported. Conclusions Cathodal tDCS therapies of 3 and 5 sessions decreased the frequency of SZs and IEDs (only between baseline and immediately post-tDCS) in adult patients with MTLE-HS compared to placebo, with mild AEs. Download : Download high-res image (230KB) Download : Download full-size image Download : Download high-res image (84KB) Download : Download full-size image
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