Abstract
Methods Fifty-five pregnant women with renal disease were compared with 110 patients matched for maternal age, maternal weight, smoking status, and gestational age at a 1: 2 ratio. Maternal renal function was assayed at the time of the combined screening and renal insufficiency was defined by serum creatinine > 90 μmol/L and renal clearance < 80 mL/min. We defined 3 groups based on renal function: kidney disease and normal function (group 1), kidney disease and renal insufficiency (group 2) and a control group (group 3). The values of nuchal translucency, PAPP-A and hCGβ as well as false-positive rates for Down syndrome screening were studied and compared between groups.
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