P02.01: Prenatal diagnosis of rhombencephalosynapsis: case series with outcome

Abstract

Objectives: The cerebellum develops over a long period of time, making it vulnerable to a wide range of disorders such as Dandy-Walker malformation and variant. The advent of three dimensional ultrasonography is an extraordinary advance in fetal medicine diagnosis. The 3DXI is technique of comparing several slices displayed on the same screen, allows a slice-by-slice approach in ascertaining the most accurate measurement to be compared with the 2D. Our objective is to make a comparative evaluation of the transverse cerebellar diameter measurement by 2D ultrasonography (Fig. 1) and 3DXI, multi-slice view in 18–24 weeks fetuses. Methods: This transversal study included 69 healthy fetuses, between 18–24 weeks. The transverse cerebellar diameter was first measured by the conventional bi-dimensional sonography technique, then by 3DXI multi-slice view, using the Medison SonoAce X8 (Medison, Korea). The Wilcoxon signed-ranks test was used to compare the data. Results: The comparison of 69 measures of the cerebellum by 2D ultrasound and 3DXI shows an effective difference between the values obtained by 2D and 3D, indicating that the 3DXI values are larger than 2D (P < 0.01). Conclusions: Our results show that the 3D evaluation of the cerebellum seems to have a statistically significant measurement difference.