Abstract
Background We explored whether cell signaling pathways related to drug resistance were activated in the stem-like cells ALDHhiCD44+ or not, and analysed the relationship between ALDHhiCD44+ cells and pathological features. Methods ALDHhiCD44+ cells and non-stem like cells ALDHlowCD44+ were separated by fluorescence-activated cell sorting from MDA-MB-231 cells. mRNA expression for Notch1 and β-catenin were estimated with Q-PCR. An immunohistochemical panel was used in patients with invasive breast carcinoma to evaluate the correlation with ALDHhiCD44+ cells with line correlation analysis. Findings The mRNA levels of Notch1 and β-catenin were higher in ALDHhiCD44+ cells than in ALDHlowCD44+ cells (p Interpretation The Notch and Wnt/β-catenin signaling pathways were abnormally activated in breast cancer stem like cells and were highly correlated with Ki67.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
