Abstract
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease with autosomal recessive inheritance pattern often seen in the Turks, Arabs, Armenians and Jews people characterised by recurrent episoded of fever and polyserositis and rash. Recently the definitive diagnosis of FMF determines by MEFV gene analysis.
Highlights
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease with autosomal recessive inheritance pattern often seen in the Turks, Arabs, Armenians and Jews people characterised by recurrent episoded of fever and polyserositis and rash
In northwest of IRAN, 216 patients with FMF diagnosis based on Tel-Hashomer criteria, referred to the genetic laboratory to12 common MEFV genes analysis
P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q mutations were analysed by using amplification refractory system for 11 of those and the PCR was performed for E148Q
Summary
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease with autosomal recessive inheritance pattern often seen in the Turks, Arabs, Armenians and Jews people characterised by recurrent episoded of fever and polyserositis and rash. The definitive diagnosis of FMF determines by MEFV gene analysis
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