P andN type copper phthalocyanines as effective semiconductors in organic thin-film transistor based DNA biosensors at elevated temperatures.

Nicholas T Boileau,Rosemary Cranston,Owen A Melville,Benoît H Lessard,Brendan Mirka

doi:10.1039/c8ra08829b

Nicholas T Boileau, Rosemary Cranston + Show 3 more

Open Access

https://doi.org/10.1039/c8ra08829b

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Journal: RSC advances	Publication Date: Jan 1, 2019
Citations: 46	License type: CC BY 3.0

Affiliation: Toronto General Hospital, University of Ottawa

Abstract

Many health-related diagnostics are expensive, time consuming and invasive. Organic thin film transistor (OTFT) based devices show promise to enable rapid, low cost diagnostics that are an important aspect to enabling increased access and availability to healthcare. Here, we describe OTFTs based upon two structurally similar P (copper phthalocyanine – CuPc) and N (hexdecafluoro copper phthalocyanine – F16-CuPc) type semiconductor materials, and demonstrate their potential for use as both temperature and DNA sensors. Bottom gate bottom contact (BGBC) OTFTs with either CuPc or F16-CuPc semiconducting layers were characterized within a temperature range of 25 °C to 90 °C in both air and under vacuum. CuPc devices showed small positive shifts in threshold voltage (VT) in air and significant linear increases in mobility with increasing temperature. F16-CuPc devices showed large negative shifts in VT in air and linear increases in mobility under the same conditions. Similar OTFTs were exposed to DNA in different hybridization states and both series of devices showed positive VT increases upon DNA exposure, with a larger response to single stranded DNA. The N-type F16-CuPc devices showed a much greater sensing response than the P-type CuPc. These findings illustrate the use of these materials, especially the N-type semiconductor, as both temperature and DNA sensors and further elucidate the mechanism of DNA sensing in OTFTs.

Highlights

Organic thin lms transistors (OTFTs) have shown promise as sensors for detecting various biological analytes such as glucose,[1] deoxyribonucleic acid (DNA),[2] thrombin,[3] bovine serum albumin[4] and brain injury markers.[5]
The N-type F16-CuPc devices showed a much greater sensing response than the P-type CuPc. These findings illustrate the use of these materials, especially the N-type semiconductor, as both temperature and DNA sensors and further elucidate the mechanism of DNA sensing in Organic thin film transistor (OTFT)
Physical adsorption of DNA,[16] electro-immobilization,[17] and chemical immobilization[18] have all been investigated for xing double stranded DNA (dsDNA), or single stranded DNA probes, to the surface of an electrode or the semiconductor material itself. ssDNA has a linear structure comprised of four different bases which will bind with a complementary ssDNA strand to form a double helix that orders the p orbitals of the bases

Summary

Introduction

Organic thin lms transistors (OTFTs) have shown promise as sensors for detecting various biological analytes such as glucose,[1] DNA,[2] thrombin,[3] bovine serum albumin[4] and brain injury markers.[5]. We describe OTFTs based upon two structurally similar P (copper phthalocyanine – CuPc) and N (hexdecafluoro copper phthalocyanine – F16-CuPc) type semiconductor materials, and demonstrate their potential for use as both temperature and DNA sensors. CuPc devices showed small positive shifts in threshold voltage (VT) in air and significant linear increases in mobility with increasing temperature.

Results

Conclusion