P 75 Long-term results of Alzheimer's and Parkinson's disease after Transcranial Pulse Stimulation (TPS) of the brain with focused extracorporeal shock waves (ESW)

Abstract

Introduction: The introduction of an ESW generator with navigation system (Neurolith, Storz Medical) is a breakthrough for the precise treatment of brain structures. It enabled the targeted TPS for Alzheimer’s patients (1). After a treatment series with TPS, Alzheimer’s patients showed after 3 months not only a significant functional gain in cognitive abilities but also a partial repair of cortical areas responsible for memory functions (3). Now case histories will be presented with long-term observations of patients with Alzheimer's and Parkinson's disease treated with TPS as a critical endeavor for future treatments. Methods: 6 patients with mild Alzheimer’s disease (Mini mental status >18) were treated initially 6 times during 2 weeks with TPS. After this, the patients received one TPS session monthly over 3 years. The results were assessed with the CERAD Plus score and compared with the data of the natural development to be expected for these patients (2). Results: During a steady enhancement of the cognitive abilities over 12 months of 12 %, the results diminished during the second year back to the baseline. A two weeks booster with TPS like the initial treatment enhanced the results again with 4,5 %. After 3 years the results were on the level of the natural history. 4 patients with Parkinson’s disease received TPS after the aforementioned protocol but had every twelve months a booster (6 sessions in 2 weeks). After the initial treatment block with TPS their symptoms improved by roughly 50% (Unified Parkinson Rating Scale) and remained stable until to date for over 4 years and in one patient for 8 years. Conclusion: It is conceivable that more frequent testing and earlier boosters would also achieve a better result in Alzheimer's patients.