Abstract
Successful implantation requires a synchronous interaction between a receptive endometrium and a developing blastocyst. Implantation failure remains an unsolved difficulty in reproductive medicine and is a major cause of infertility in otherwise healthy women. Evidence regarding the contribution of E-Cadherin, a calcium-dependent cell-cell adhesion molecule, in the maternal-embryo interaction is not well established. We hypothesize that disruption in E- Cadherin expression and function may result in poor endometrial receptivity and may be a significant basis for repeated implantation failures in IVF (RIF-IVF).
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