Abstract
an increase in global, and no significant changes were found in the regions of interest studied. Although the opioid dependent patients craved at a high level there was no association with opioid receptor availability. However, in the alcohol dependent group, an increase in craving was significantly associated with increased availability of opioid receptors in the striatum and whole brain. We have shown an increase in opioid receptors in early abstinence from dependent alcohol and opioid use. Although the results in our alcohol dependent group did not reach significance they are consistent with another recent study (Heinz et al., 2005). This finding is most likely due to an acute increase in receptor number in early abstinence.
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