Abstract
Trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) is widely used as one of salvage line treatment options in metastatic colorectal cancer (mCRC) patients. In Japan, three vascular endothelial growth factor (VEGF) inhibitors, BEV, ramucirumab (RAM), and aflibercept (AFL), are approved for mCRC patients with second-line chemotherapy including irinotecan. It remains unclear the effect of the difference of pretreatment VEGF inhibitors in clinical outcomes of FTD/TPI plus BEV.
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