Abstract
Introduction. Many previous studies tried to find etiologic genes of alcohol dependence. Among these genes, alcohol metabolizing hepatic enzyme genes (ADH2 and ALDH2) and mu-opioid receptor gene (OPRM1) have become a great interest recently. Accordingly, our purpose is to investigate gene-gene interaction of alcohol metabolizing hepatic enzyme gene and mu-opioid receptor gene in the Korean male and female patients with alcohol dependence. Methods. The subjects were 241 male alcohol-dependent patients, 60 female alcohol-dependent patients, 79 male normal controls, and 59 female normal controls. The frequencies of the ADH2 (1/1 and 2+), ALDH2 (1/1 and 2+), and OPRM1 All8G (A/A and G+) genotypes were investigated in male and female alcohol-dependent patients and the normal control group. Results. In female alcohol-dependent patients, who has ADH2 1/1 genotype, OPRM1 G+ genotype frequencies were significantly higher than the female normal control group. Furthermore, OPRM1 G+ genotype frequencies were significantly higher in the female alcohol-dependent patients who have ALDH2 2+ genotype, compared to the female normal control group. Conclusion. G+ genotype frequency in OPRM1 was higher only in female alcoholics, who had low activity of ADH2 or ALDH2. These results suggest that the cause of drinking in women is strongly related to inducing reward.
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