Abstract
Neuroendocrine neoplasms (NEN) are rare tumors and vary from well-differentiated (low grade) neuroendocrine tumors (NETs) to undifferentiated (high grade) tumors, named as neuroendocrine carcinoma. This classification of NETs is based mainly on Ki67 proliferation index that grades NETs into low proliferative tumors (GI, GII) and high proliferative tumors (GIII). The aim of this study was to evaluate the clinicopathological characteristics of patients with GIT neuroendocrine tumors in the United States, diagnosed from 1990 till 2015.
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