Abstract
The hyperglycemia-induced endothelial cell dysfunction is a key event in the onset and progression of cardiovascular disease (CVD), protection of vascular endothelial cells represents an important strategy for the diagnosis of CVD. Previous studies suggest that the polyphenols of a wine pomace (WP) could be able to modulate endothelial dysfunction, increase the levels of nitric oxide and decrease the levels of ROS. The objective of this study was to elucidate some of the possible pathways involved in the potential protective effects against endothelial dysfunction and oxidative damage in the vasculature of WP product. For this, we evaluated the Nrf2/ARE and IKK/IκB/NF-κB pathway in high glucose-induced oxidative stress in the endothelial cell line HUVECs EA.hy926. Analysis revealed that WP product-mediated antioxidant effects were due to up-regulation of cellular anti-oxidant genes, such as HO-1 and NQO-1 via promotion of the transcriptional activity of Nrf2 and down-regulation of the NF-κB pathway. These results suggest that WP product may represent a promising intervention in diabetic-associated cardiovascular diseases by activating the Nrf2-dependent cellular anti-oxidant defense system.
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