Abstract
Diabetic mellitus induces many pathophysiological changes in skin. The effect of UV light on chronic exposure in diabetic and normal skin was investigated. Hairless mice skin, diabetic (D) and non-diabetic (ND), were exposed to UVA and UVB radiation 3 times per week for 18 weeks. The irradiation dose was equal to 0.75 M.E.D during the first week and increased by 25% each week until the maximal dose was 3.5 M.E.D. Diabetes was induced by streptozotocin injection. Stratum corneum hydration of D mice was significantly lower than ND (p This results suggest that D mice presented more severe inflammation, photoageing and hyperpigmentation after chronic UV irradiation.
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