Abstract
Use of active site-targeting inhibitor is an effective approach leading to pharmacological inventions. Heat shock cognate protein A8 (HSPA8) has been found as a receptor of VGF derived bioactive peptide TLQP-21 in SH-SY5Y cells. So, it was of much interest to carry out this study in order to observe whether Oxymatrine (OMTR), an inhibitor of HSPA8, inhibits the binding of TLQP-21 to the surface of intact, live SH-SY5Y cells. The results confirmed, as expected, that OMTR reduces the binding of TLQP-21 to the surface of intact, live SH-SY5Y cells, with a strong conclusion that the binding of TLQP-21 to the surface of SH-SY5Y cell model was through HSPA8. The inhibition efficacy of OMTR potentiates its application in drug targeting.
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