Abstract
Purpose To investigate the oxygen permeability (Dk) and oxygen transmissibility (Dk/t) of amniotic membrane (AM), and tear oxygen tension beneath AM in rabbits. Design Experimental study. Method The water content of AM was measured to calculate Dk and Dk/t, and compared with those of a therapeutic soft contact lens (TSCL).The tear oxygen tension beneath AM and TSCL was also measured in four male albino rabbits. Results The average water content of AM was significantly higher than that of TSCL (96.8 ± 0.8% (mean ± SD) vs 78%, P = .0006), giving rise to a significantly higher Dk and Dk/t in AM as compared with TSCL (142.8 ± 4.7 vs 65.3, respectively, P = .0012, and 92.9 ± 3.0 vs 29.7, respectively, P = .0008). The average tear oxygen tension under AM was also higher than TSCL (94.9 ± 2.9 vs 59.1 ± 4.9 mm Hg, P = .0006). Conclusions These findings support the rationale of using AM as a superior bandage in treating persistent corneal epithelial defects or ulcers.
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