Abstract
Oxycodone prolonged-release (PR) tablets provide a convenient twice-daily oral opioid option for the treatment of chronic pain, including cancer-related pain. Its analgesic efficacy in these settings has been established in clinical trials and extensive clinical practice and appears to be generally similar to that of oxycodone immediate release (IR) and long-acting oral formulations of other opioids. Oxycodone PR has a tolerability profile consistent with that of other opioids and is associated with less ‘drug liking’ and lower ‘drug highs’ than oxycodone IR when taken appropriately (i.e. as intact tablets, not crushed).
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