Abstract
Some oxovanadium(IV) complexes of SA/SSA and 5, 10, 15, and 20-meso-tetraphenylporphyrin (H2tpp) with unidentate and bidentate nitrogen donors have been synthesized and characterized by elemental analysis, conductivity measurements, magnetic susceptibility, UV-Vis, IR, mass spectroscopy, TGA/DTA, and 1H, 13C and 51V NMR studies to investigate the steric and electronic effects of axial ligands on the properties of porphyrins. On the basis of these studies, it has been investigated that the axial ligands bind to the sixth coordination site of the vanadium ion to form a relatively stable six-coordinate-porphyrin complex where as in the case of SA/SSA complexes the nitrogen donors bind to the equatorial position giving square pyramidal geometry. The in vitro cytotoxicity against human cancer cell lines and antimicrobial activities of the synthesized compounds have been done against various fungal and bacterial pathogens. The [VO(SA/SSA)L/L-L] complexes were found to possess higher antibacterial, antifungal activity and in vitro cytotoxicity against human cancer cell lines than VO(tpp)L complexes.
Highlights
Macrocyclic nitrogen donor ligands [1] have received special attention because of their versatile coordination modes [2] and for their biological activities, that is, toxicity against bacterial [3] and fungal growth, anticancerous [4], and other biochemical properties [5]
The analytical and spectroscopic results showed that the complexes of [VO(SA/sulfosalicylic acid (SSA))] with unidentate nitrogen donors have general formula [VO(SA)(L)2]/[VO(SSA)(L)2] where L = substituted pyridines and with bidentate nitrogen donors the general formula is [VO(SA)(L-L)]/[VO(SSA)(LL)] where (L-L = ethylene diamine, 2,2-bipyridyl and 1,10phenanthroline)
The [VO(SA/ SSA)(L/L-L)] complexes in DMSO have shown the molar conductance values in the range of 2–9 Ω−1 cm2 mol−1 revealing their neutral character and they exhibit magnetic moments in the range 1.73–1.79 B.M. which is in accordance with the square pyramidal geometry around the metal atom in the complex and the monomeric nature of these complexes (Table 1) [18]
Summary
Macrocyclic nitrogen donor ligands [1] have received special attention because of their versatile coordination modes [2] and for their biological activities, that is, toxicity against bacterial [3] and fungal growth, anticancerous [4], and other biochemical properties [5]. Such ligands, for example, porphyrins, salicylates, and sulphosalicylates, are known to play a very important and vital role in the stability of the metal complexes with the factor of having specific cavity size, stereochemical rigidity, flexibility, and ability to coordinate with metal atom [6]. Structural correlation of these complexes has been made and a square pyramidal geometry around [VO(SA/SSA)L/L-L] and an octahedral geometry around [VO(tpp)L] complexes are proposed on the basis of electronic spectroscopic studies
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