Abstract
Copper(II) complexes of 2-(methylthiomethyl)anilines (1a–1f) have been obtained and characterized by elemental analyses, IR, electronic spectra, conductivity, and X-ray crystallography. The complexes (2a–2f) have the structural formula [CuCl2L] with the bidentate ligand coordinating through sulfur and nitrogen. The single crystal X-ray diffraction data reveal that the copper complex (2f) has a tetragonally distorted octahedral structure with long Cu–Cl equatorial bonds. Magnetic susceptibility measurements indicate the availability of one unpaired electron in the complexes and the conductivity measurements in DMF show their behaviour as nonelectrolytes. The solid reflectance spectra and the electronic spectra of the complexes in DMSO were determined. The ligands and their copper complexes were screened for in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, and C. albicans. The methoxysubstituted complex (2c) showed more promising antibacterial activity against S. aureus and B. subtilis than other compounds at the concentration tested.
Highlights
The alkylthioalkylated anilines have found application as intermediates in production of many organic compounds [1,2,3] including dyes, rubber, and herbicides [4]
The spectral, structural, and antimicrobial properties of copper(II) complexes of 2-(methylthiomethyl)anilines are reported with the spectral property and antimicrobial activity of the complexes compared to their corresponding ligands
The synthesis route for the copper complexes is shown in Scheme 1
Summary
The alkylthioalkylated anilines have found application as intermediates in production of many organic compounds [1,2,3] including dyes, rubber, and herbicides [4] They act as coordinating ligands due to the presence of the aniline nitrogen and the thioether sulfur in their moiety. Donor groups commonly found in many known biologically active compounds and ligands used in pharmaceutical synthesis include the nitrogen, oxygen, sulfur, and chlorine atoms. Such biopotent organic compounds with their metal complexes are being explored for their activity against a wide range of microorganisms. The spectral, structural, and antimicrobial properties of copper(II) complexes of 2-(methylthiomethyl)anilines are reported with the spectral property and antimicrobial activity of the complexes compared to their corresponding ligands
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