Abstract
Oxidative stress in the heart of rats exposed to acute intermittent hypobaric hypoxia
Highlights
Hypobaric hypoxia causes increase in reactive oxygen species (ROS) production, increase in oxidative damage caused by ROS attacks on the macromolecules such as lipids, proteins and DNA [3]
We investigated the impact of acute intermittent hypobaric hypoxia on oxidative stress status in heart organ to predict heart health in the future
Results of MDA level in rat heart after acute intermittent hypobaric hypoxia exposure show no significant difference in MDA level between group I, II, III and control
Summary
Hypobaric hypoxia causes increase in reactive oxygen species (ROS) production, increase in oxidative damage caused by ROS attacks on the macromolecules such as lipids, proteins and DNA [3]. Examination of specific activity of catalase was conducted using hydrogen peroxide (H2O2) which added to samples [13]. The activity of catalase enzyme was obtained by the reduction of the absorbance between the first reading(30 sec after samples mixing) and the second reading(3 min later after first reading). Malondialdehyde level in rat’s heart can be seen in Fig. 2 after exposure to acute intermittent hypobaric hypoxia.
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