Oxidative Stress Activity in Rats with Subtotal Brain Ischemia Under the Conditions of The Use of Modulators of the L-Arginine-No Pathway

Abstract

Acute cerebrovascular accident is one of the most urgent problems in modern medicine. The urgency of the problem of cerebrovascular diseases can rightfully be defined as extraordinary, requiring the concentration of efforts of specialists of different profiles to solve it. One of the promising neuroprotective amino acids is L-arginine. Most of the effects caused by this amino acid are associated with its ability to increase the formation of NO, acting as a source for its formation. It has been shown that the use of L-arginine reduces the size of the infarct, reduces vascular tone and causes a hypotensive effect, prevents and corrects ischemic and reperfusion damage to the brain and other organs. The use of "L-arginine" in animals of the group with cerebral ischemia and the introduction of a non-selective NOS inhibitor – L-NAME did not have a significant positive effect. Thus, nitric oxide hyperproduction has been studied by stimulating synthesis by introducing the substrate L-arginine, and inhibition by using the non-selective NO synthase inhibitor N-nitro-L-arginine methyl ester.