Abstract
Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1st and the 2nd trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3rd trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.
Highlights
Oxidative status of maternal blood is an important parameter of pregnancy [1]
The activity of superoxide dismutase (SOD) in erythrocytes was about two-fold lower in thrombophilias than controls during the entire pregnancy (Fig 1A)
Pro-reductive oxidative status is implicated by higher R-SH levels and by lower oxidation-reduction potential (ORP) in plasma, as well as by lower activities of SOD, CAT and glutathione reductase (GR) in erythrocytes
Summary
Oxidative status of maternal blood is an important parameter of pregnancy [1]. It has a regulatory role in the processes of placental angiogenesis and development, gestation maintenance, and the recognition of fetus-cells and immune maternal responses [2,3,4]. A positive correlation has been established between oxidative status of the mother and the neonate [5]. It is important to note that several studies have found that normal pregnancy is characterized by mild. Redox dynamics of blood in thrombophilic pregnancy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
